Structural and Computational Characterization of the SHV-1 -Lactamase- -Lactamase Inhibitor Protein Interface*
نویسندگان
چکیده
From the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0684, the Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, the Biophysics Group and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, and **Research Service, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106
منابع مشابه
Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study
β-Lactamase inhibition is an important clinical strategy in overcoming β-lactamase-mediated resistance to β-lactam antibiotics in Gram negative bacteria. A new β-lactamase inhibitor, avibactam, is entering the clinical arena and promising to be a major step forward in our antibiotic armamentarium. Avibactam has remarkable broad-spectrum activity in being able to inhibit classes A, C, and some c...
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